MS patients in a small NYU Langone Medical Center-led pilot of neuromodulation and cognitive training using telemedicine supervision experienced significant improvement in complex attention and reaction time. Non-invasive transcranial direct current brain stimulation (tDCS) was added to a previously tested cognitive training program for MS patients. Telemedicine (real-time video) was used to deliver the training, monitor patients in the program and provide follow-up support.
The study control was a cognitive training (CT)-only group. According to the abstract, “after ten sessions, the tDCS group (n = 25) compared to the CT only group (n = 20) had significantly greater improvement in complex attention (p = 0.01) and response variability (p = 0.01) composites. The groups did not differ in measures of basic attention (p = 0.95) or standard cognitive measures (p = 0.99).” These results corresponded to the stimulation area in the dorsolateral prefrontal cortex, according to the lead researcher Leigh Charvet, PhD.
The current used in the tDCS unit helps neurons fire more readily, versus making them fire. The tDCS unit used was likely provided by NYC-based Soterix Medical, a developer of neuromodulation systems used in clinical trials. One of the study authors, Abhishek Datta, PhD, is their CTO.
The research is also promising in helping to deliver therapy to MS patients at home, reducing the travel need on both sides, and to develop analytics to optimize medication. In future, the researchers hope to expand the study group to Parkinson’s disease patients. MedCityNews, Neuromodulation (the official journal of the International Neuromodulation Society; abstract only, full study requires additional access)