TBI drug in potential trial with former NFL players’ association

Breaking news in the US today on a topic we’ve been following. Maryland-based Neuralstem, a developer of neurogenic drugs, announced this morning that it is working with the National Football League Alumni Association (NFLAA) to develop a trial of their NSI-189 for treating NFL alumni members suffering from traumatic brain injuries (TBI). According to their release, NSI-189 (or NS1-189, both are used) is currently in a Phase Ib clinical trial to treat major depressive disorder. Because it appears to work by stimulating neurons in the hippocampus, a region of the brain that atrophies in depression, this could also apply to brain injury. While this announcement is perhaps more than it seems–a Phase I clinical trial is ‘early days’, to make it through all four phases (I-IV) may take a decade, and now the developer is switching around the treatment condition–the drug itself has received support from DARPA and NIH which are both closely concerned with TBI. In addition, working with the NFLAA will help Neuralstem find subjects for the trials. PR Newswire via Baltimore Business Journal 

Previously in TTA on TBI and the NFL: Further sad confirmation of CTE, Brain injury research study, NFL donates $30 million to NIH, Combating TBI on the battle and football fields.

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