Search Results for cte

BU CTE Center post-mortem presentation on Aaron Hernandez: stage 3 CTE

is found in players at least 20 years older. In a 2016 New York Times interview after the death of Oakland Raiders quarterback Ken Stabler, Dr. McKee correlated long careers plus the increasing age of the player with the severity of CTE. Dr. McKee confined herself to presenting the pathology, but the CTE Center’s research has associated CTE with aggressiveness, explosiveness, impulsivity, depression, memory loss and other cognitive changes. The CTE Center has pioneered research in the prevalence of CTE in NFL players’ brains [TTA 26 July] and is conducting longitudinal research on the relationship between concussive and sub-concussive head... Continue Reading

Youth football playing may contribute to long-term cognitive, behavioral issues: BU study

in past youth football for the average age respondent (51) and the self-reporting methodology. It is not a risk study for CTE, nor is it intended to advocate the reduction or elimination of youth football. It does advocate for more longitudinal studies. This Editor has attended at least two talks by the CTE Center’s Robert Stern, MD, and he has been never been content with limiting his study to either football or to purely concussive damage. Why is this research important to healthcare and to technology? (I’ll expand upon a previous closing.) First, because repetitive brain trauma–concussive and sub-concussive–now has... Continue Reading

CTE found in 99% of former, deceased NFL players’ brains: JAMA study (updated)

click to enlarge Updated for additional information and analysis at conclusion. In the largest-ever case study published of CTE–chronic traumatic encephalopathy—VA Boston Healthcare System (VABHS) and the Boston University School of Medicine’s CTE Center found mild to severe CTE pathology in nearly all of the brains of former football players studied. Jesse Mez, MD, BU Medical assistant professor of neurology and lead author on the JAMA study, said that “The data suggest that there is very likely a relationship between exposure to football and risk of developing [CTE].” The CTE is marked by defective tau (stained red in the brain... Continue Reading

Congressional investigation confirms NFL attempted to influence concussion, CTE research

Not shocking to our Readers. In December, sports network ESPN reported that the National Football League (NFL) refused to fund research on detecting in vivo chronic traumatic encephalopathy (CTE) from a long-term $30 million unrestricted grant to the National Institutes of Health (NIH) [TTA 23 Dec 15]. A 91-page report by Democratic members of the House Committee on Energy and Commerce, which started after the December reports, confirmed that the NFL improperly attempted to shape the research after the grant, violating NIH peer-review process policies that stipulated no grantor interference. The NFL specifically objected to the objectivity of Boston University’s... Continue Reading

NIH funds in vivo CTE research with $16 million–$0 from NFL; “Concussion” released

Related reading: Science Underground ‘This is your brain on CTE’ podcast with Dr Stern. Famed NY Giants quarterback and later broadcaster Frank Gifford, who died earlier this year aged 84, also had behavioral signs of CTE in the latter part of his life, which was confirmed upon a family-authorized brain autopsy. Daily Mail We’ve been covering CTE and related brain injuries since at least 2012. Our CTE-related coverage since late 2012 is indexed here; also our index on TBI gives a broader perspective. Yahoo’s article on Concussion’s director has a few comments by this Editor. The movie itself has created... Continue Reading

TBI, early brain aging and a seismic analogy

...military veterans who sustained mild brain injuries experience the heightened and uncontrollable emotionality of pseudobulbar affect (PBA). This article in the Genetic Literacy Project website works with an earthquake analogy: that there are P-waves (blast pressure) that compress tissues and disrupt neuronal communication, and in the long term accelerate brain aging and cognitive decline. Something sports injury, CTE researchers and research organizations within the military such as DARPA and DoD should be investigating. Hat tip to author and reader Dr Ben Locwin via Twitter. An abundance of related reading in TTA can be found in searches under TBI and chronic... Continue Reading

Possible early detection test for chronic traumatic encephalopathy (CTE)

A research study published today in the Proceedings of the National Academy of Sciences (US) presents the results of screening 14 retired professional American football players with suspected CTE. Using a tau-sensitive brain imaging agent, [F-18]FDDNP, the California and Illinois-based researchers were able to detect the abnormal accumulation of tau and other proteins, in the distinct CTE pattern, in the brains of living subjects who had received, during their playing careers, multiple concussions and head trauma. Of the 14, one had been diagnosed with dementia, 12 with mild cognitive impairment and one with no symptoms. Previous studies, such as Robert... Continue Reading

Testing the ‘blast response’ of synthetic bone

While protection against concussive and sub-concussive head blows that lead to brain trauma (TBI) and may lead long-term to chronic traumatic encephalopathy (CTE) is being developed in several areas, by DARPA, US Army research, universities and the NFL‘s helmet providers, the final test has to involve cranial bone similar to those belonging to 20-30 year olds. Testing on humans is out of the question, deceased animal and older human crania are dissimilar and surgical implants do not react like real bone. The US Army Research Laboratory (ARL) along with university partners are developing synthetic cranial bone that behaves like real... Continue Reading

‘Brain Games’ on preventing, diagnosing sub-concussive brain trauma

may be leading to CTE. The next step is to find biomarkers (the Dr. Inga Koerte research)–the DETECT study using lumbar puncture– and brain imagery (early PET scan, Siemens) to locate abnormal tau levels so that CTE can be diagnosed earlier and more definitively. Dr. Stern concluded that his work has only reached the ‘infant stage’ of development. Questions which badly need answers: Is CTE common? Why do some contact sports athletes get it and others never do? What are the risk factors? Genetics? Exposure? Far larger sample sizes–and funding–are needed, and unfortunately NIH funding has grown scarce. [A note... Continue Reading

NIH-NFL research grants on brain injury awarded (US)

In September 2012, the National Football League (NFL) donated $30 million to the Foundation for the National Institutes of Health (FNIH) to focus on brain injury. The Sports and Health Research Program (SHRP) now has a somewhat wider scope inclusive of joint diseases, sudden cardiac arrest, sickle cell anemia and hydration/heat injury. Last week they announced eight projects to be supported. Two ($6 million each) are cooperative agreements focusing on brain injury and after multiple concussions. These research projects are: Boston University, which has pioneered major CTE research [TTA 5 June], and the VA on CTE; the pathology of CTE... Continue Reading